Dosing
CrCl > 80: 15 - 30 mg/kg po q 24 h.
CrCl 80-50: 15 - 30 mg/kg po q 24 h.
CrCl 50-10: 15 - 30 mg/kg po q 24 h.
CrCl < 10: 12-20 mg/kg po q 24 h.
Hemodialysis: 12 to 20 mg/kg/day OR 40 mg/kg three times weekly OR 60 mg/kg twice weekly.
Peritoneal dialysis:
Important side effects
Arthralgia (common), anemia, hepatotoxicity, hyperuricemia, nausea, vomiting.
Important drug interactions
Cyclosporine, ethionamide, probenecid, rifampin, zidovudine.