Dosing
CrCl > 80: depends on what your treating.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Leukopenia, megaloblastic anemia, rash, Steven's-Johnson syndrome (rare).
Important drug interactions
Aurothioglucose, folic acid, lorazepam, methotrexate, sulfamethoxazole, trimethoprim, zidovudine.
Rants and Screeds
Pearls
Treatment of choice
Use for
Prophylaxis of toxoplasma and malaria.