Dosing
CrCl Formula
CrCl > 80: 1 - 2 g iv q 6 - 12 h.
CrCl 80-50: 1 - 2 g iv q 6 - 12 h.
CrCl 50-10: 1 - 2 g iv q 6 - 12 h.
CrCl < 10: 1 - 2 g iv q 6 - 12 h.
Hemodialysis: dose after dialysis
Peritoneal dialysis:
Important side effects
Hypoprothrombinemia with increase in protime.
Important drug interactions
Heparin, warfarin due to hypoprothrombinemia with increase in protime.
Rants and Screeds
Pearls
No longer available in US.
Treatment of choice
Use for
Any thing you would use a third generation cephalosporin for: Cellulitis, Cholangitis, Cholecystitis, Gonorrhea, Intra abdominal infections, PID, Peritonitis, Pneumonia, Meningitis, ocular infections, Osteomyelitis, Otitis media, peritoneal dialysis, Peritonitis, proteus mirabilis infections, Pneumonia, Sepsis, UTI.
Don't use for
Class
Third generation cephalosporin.
Last Update: 08/05/19.