Infectious Disease Compendium

Letermovir

Not available in US since 2012)

Dosing

480 mg per day

240 mg per day in patients taking cyclosporine

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

CMV prophylaxis in allogeneic hematopoietic stem cell transplant patients (PubMed).

Don't use for

Class

CMV multiplication involves the cleaving of concatemeric genomic viral DNA and the packaging each genome into virus capsids, which is is mediated by the CMV–terminase complex: UL51, UL56, and UL89. But you knew that. Letermovir inhibits CMV replication by binding to components of the terminase complex.