Dosing
CrCl > 80: 3 g q 4-6 h.
CrCl 80-50: 3 g q 4 - 6 h.
CrCl 50-10: q 6 - 8 h.
CrCl < 10: 2 g q 12 h.
Hemodialysis: 3 g then 2 g q 12 h.
Peritoneal dialysis: 3 g q 12 h.
Important side effects
Anaphylaxis, coagulation abnormalities; bleeding time and platelet aggregation, convulsions, hypersensitivity reactions, hypokalemia, rash, thrombophlebitis.
Important drug interactions
Rants and Screeds
A drug of historical interest.
Pearls
Treatment of choice
Use for
Guess if you want a half assed gram-negative penicillin, I suppose you could use this. Arthritis, Cellulitis, Empyema, Endometritis, eye infections, gynecologic infections, Intra abdominal infections, Neutropenic fever, Osteomyelitis, Pneumonia, Sepsis, Sinusitis, surgical prophylaxis, UTI.
Don't use for
Class
Penicillin.