Dosing
CrCl > 80: 500 mg po q 24.
CrCl 80-50: no change.
CrCl 50-10: no change.
CrCl < 10: no change.
Hemodialysis:
Peritoneal dialysis:
Important side effects
GI.
Important drug interactions
Cyclosporine, digoxin, dofetilide, ergot derivatives, fentanyl, pimozide.
Rants and Screeds
Pearls
Treatment of choice
Use for
Nothing. It is less active against everything compared to erythromycin. So use erythromycin instead. Bronchitis, Cellulitis, COPD exacerbation, Pharyngitis, Pneumonia- community acquired, tonsillitis.
Don't use for
Class
Macrolide.