Not available in US since 2012)
Dosing
480 mg per day
240 mg per day in patients taking cyclosporineHemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Rants and Screeds
Pearls
Treatment of choice
Use for
CMV prophylaxis in allogeneic hematopoietic stem cell transplant patients (PubMed).
Don't use for
Class
CMV multiplication involves the cleaving of concatemeric genomic viral DNA and the packaging each genome into virus capsids, which is is mediated by the CMV–terminase complex: UL51, UL56, and UL89. But you knew that. Letermovir inhibits CMV replication by binding to components of the terminase complex.