Dosing
CrCl > 80: 200 mg tid. Only comes po.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
"Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme."(Pubmed).
Important drug interactions
These drugs interact with damn near everything else so check with you pharmacist or this reference at CID.
Rants and Screeds
Pearls
Low serum levels are associated with breakthrough fungal infections (PubMed). And high levels are associated with toxicity (PubMed). So iff you can, get a level in patients on the drug long term .
Treatment of choice
Use for
Aspergillus fumigatus - disseminated, Candida, Cryptococcus neoformans, Fusarium, disseminated phaeohyphomycosis, disseminated zygomyces. Fungal prophylaxis in graft vrs host disease.
Don't use for
Class
Triazole.