Dosing
CrCl > 80: The initial dosage is 250 mg bid (or as a single dose at bedtime), increased by 250 mg daily until 1 g/day in divided doses. Usually, 500 to 750 mg is the maximal tolerated dose.
CrCl 80-50:
CrCl 50-10:
CrCl < 10:
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Aminosalicyclic acid, cycloserine, ethanbutol, isoniazid, pyrazinamide, rifampin; all increase toxicity.
Rants and Screeds
Pearls
Treatment of choice
Use for
A second line treatment for Tuberculosis and other Mycobacterium infections.