Dosing
CrCl > 80: 4-5 gm iv q 8 h.
CrCl 80-50: 4-5 gm iv q 8 h.
CrCl 50-10: 4-5 gm iv q 12 h.
CrCl < 10: 4-5 gm iv q 24 h.
Hemodialysis:
Peritoneal dialysis:
Important side effects
Important drug interactions
Methotrexate, probenecid, vecuronium.
Rants and Screeds
Pearls
For Pseudomonas, Piperacillin alone is BETTER than Piperacillin/Tazobactam. Since Pseudomonas does not make a beta lactamase that is inhibited by tazobactam, the tazobactam instead acts as a competitive inhibitor to the Piperacillin, raising the mic 2-4 times.
Treatment of choice
Use for
It is the best anti pseudomonas penicillin we got. Yes, got. abdominal hysterectomy, Arthritis, Cellulitis, Otitis media and Sinusitis infections, Endometritis, Endophthalmitis, Gonorrhea, Intra abdominal infections, Neutropenic fever, Osteomyelitis, PID, Pneumonia, Sepsis, surgical prophylaxis, UTI, vaginal hysterectomy.
Don't use for
Class
Penicillin.