Dosing
CrCl > 80: 500 mg - 1 g iv q 6 h.
CrCl 80-50: 500 mg iv q 6 - 8 h.
CrCl 50-10: 500 mg q 8 - 12 h.
CrCl < 10: 250 - 500 mg iv q 12 h.
Hemodialysis: 250 - 500 mg after then q 12.
Peritoneal dialysis:
Important side effects
1) seizures if not dosed for CrCl.
2) 30% chance of cross reaction if a type 1 reaction to penicillin. Did you see that? 30%!. Holy spit. (Surprise, I actually censored myself).
Important drug interactions
Cyclosporine, ganciclovir, theophylline.
Rants and Screeds
Pearls
Treatment of choice
Use for
Damn near anything. Anthrax, Arthritis, Cellulitis, Cystic fibrosis, Diverticulosis/itis, Endocarditis, gynecologic infections, Intra abdominal infections, Meningitis, Neutropenic fever, Osteomyelitis, Peritonitis, Pneumonia, Sepsis, UTI.
Don't use for
Class
Carbapenem