For up-to-date information, go to http://hivinsite.ucsf.edu/tables.
Treatment naive or with no resistance mutations: 50 mg qd
Treatment experienced with known or suspected resistance mutations
OR
given with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin, other UGT1A/CYP3A inducers 50 mg bid
Important side effects
Insomnia, headache, and, rarely, rash including hypersensitivity reaction
Increases creatinine by inhibiting creatinine tubular secretion but does not effect actual GFR.
Important drug interactions
Many, serum levels are decreased by efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin.
Absorption decreased by antacids, laxative and minerals.
Rants and Screeds
Pearls
Treatment of choice
HIV as part of combination therapy.
Use for
Don't use for
Class
Integrase inhibitor